Membrane traffic: endocytotic dynamics and regulation
نویسندگان
چکیده
Endocytosis plays a central role in many cell biological processes. Talks at the Minisymposium on “Membrane Traffic: Dynamics and Regulation,” Endocytosis Section, mainly focused on specific mechanistic aspects of endocytosis, addressing the questions of how cargoes are sorted into different endocytic vesicles and how vesicles pinch off from the plasma membrane or bud into multivesicular bodies and move within the cytoplasm.
منابع مشابه
The S362A mutation block ROMK2 (Kir1.1b) endocytosis in Xenopus laevis oocyte membrane .
Abstract The S362A mutation block ROMK2 (Kir1.1b) endocytosis in Xenopus laevis oocyte membrane . Saeed Hajihashemi1 , 1-Assistant professor, PhD in Physiology, Department of Physiology, School of Medical science, Arak University of Medical Sciences. Introduction: ROMK channel is localized on the apical membrane of the nephron. Recent studies suggest that endocytosis of ROMK chan...
متن کاملPathways for degradation of connexins and gap junctions.
Gap junctional proteins, connexins, and gap junctional plaques are short-lived. Three pathways for their degradation have been proposed: (1) misfolded/abnormally oligomerized connexins are retrogradely translocated and degraded by the proteasome through endoplasmic reticulum-associated degradation; (2) connexins (as monomers or oligomers) may traffic directly from an early secretory compartment...
متن کاملRabphilin-3A: A Multifunctional Regulator of Synaptic Vesicle Traffic
We have investigated the function of the synaptic vesicle protein Rabphilin-3A in neurotransmitter release at the squid giant synapse. Presynaptic microinjection of recombinant Rabphilin-3A reversibly inhibited the exocytotic release of neurotransmitter. Injection of fragments of Rabphilin-3A indicate that at least two distinct regions of the protein inhibit neurotransmitter release: the NH2-te...
متن کاملControl of Rho GTPase function by BAR-domains
Cytoskeletal dynamics are key to the establishment of cell polarity and the consequent coordination of protrusion and contraction that drives cell migration. During these events, the actin and microtubule cytoskeleton act in concert with the cellular machinery that controls endo-and exocytosis, thus regulating polarized traffic of membranes and membrane-associated proteins. Small GTPases of the...
متن کاملCalcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
In many cells, endocytotic membrane retrieval is accelerated by Ca2+. The effect of Ca2+ on single endocytotic vesicles and fission pore kinetics was examined by measuring capacitance and conductance changes in small membrane patches of insulin-secreting INS-1 cells. In intact cells, elevation of Ca2+ by glucose stimulation induced a 1.8-fold increase in membrane internalisation. This surprisin...
متن کامل